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Dietary Supplement Climea Forte 30tabs.

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In the WHI estrogen plus progestin substudy, there was a statistically non-significant increased risk of CHD events reported in women receiving daily CE (0.625 mg) plus MPA (2.5 mg) compared to women receiving placebo (41 versus 34 per 10,000 women-years). 1 An increase in relative risk was demonstrated in year 1, and a trend toward decreasing relative risk was reported in years 2 through 5. Climea Forte helps in relieving the symptoms of menopause, including hot flushes, sweating, anxiety, irritability (hops extract). Supports weight control and helps maintain digestive comfort (flax). Supports the maintenance of healthy bones (calcium and vitamin D), contributes to the reduction of tiredness and fatigue (vitamin B6, folates). Also helps to protect cells against oxidative stress (vitamin E) and supports the proper functioning of the nervous system (vitamin B6). b) Adverse reactions occurring at rate of ≥ 5 percent in Climara Forte trials of clinical efficacy versus placebo and versus active comparator After daily administration, the spray formulations of estradiol reach steady state within 7-8 days. After 3 sprays daily, Cmax is about 54 pg/mL with a Tmax of 20 hours. AUC is about 471 pg•hr/mL.

Subgroup analyses of women 50 to 59 years of age suggest a statistically non-significant reduction in CHD events (CE [0.625 mg]-alone compared to placebo) in women with less than 10 years since menopause (8 versus 16 per 10,000 women-years). 1 Rossouw JE, et al. Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause. JAMA. 2007;297:1465-1477. tablets contain: 250 mg soybean extract, including 100 mg isoflavones, 60 mg hop cone extract, 20 mg flax seeds, 800 mg (100%) calcium *, vitamin D 50 µg (2000 I.U.) (1000%) *, vitamin B6 2.8 mg (200%) *, vitamin E 12 mg alpha-tocopherol equivalent (100%) *, folic acid 400 µg (200%) *. Start therapy with 0.025 mg per day applied to the skin once weekly. The dose should be adjusted as necessary to control symptoms. Clinical responses (relief of symptoms) at the lowest effective dose should be the guide for establishing administration of the Climara Forte transdermal system, especially in women with an intact uterus. Prevention Of Postmenopausal OsteoporosisIn this substudy, prior use of estrogen-alone or estrogen plus progestin therapy was reported by 26 percent of the women. The relative risk of invasive breast cancer was 1.24, and the absolute risk was 41 versus 33 cases per 10,000 women-years, for CE plus MPA compared with placebo. Among women who reported prior use of hormone therapy, the relative risk of invasive breast cancer was 1.86, and the absolute risk was 46 versus 25 cases per 10,000 women-years for CE plus MPA compared with placebo. Among women who reported no prior use of hormone therapy, the relative risk of invasive breast cancer was 1.09, and the absolute risk was 40 versus 36 cases per 10,000 women-years for CE plus MPA compared with placebo. In the same substudy, invasive breast cancers were larger, were more likely to be node positive, and were diagnosed at a more advanced stage in the CE (0.625 mg) plus MPA (2.5 mg) group compared with the placebo group. Metastatic disease was rare, with no apparent difference between the two groups. Other prognostic factors, such as histologic subtype, grade and hormone receptor status did not differ between the groups 6. Preparat zawiera wyciągi roślinne iwitaminy. 1tabletka zawiera: 50 mg izoflawonów znasion soi, 30 mg wyciągu zszyszek chmielu, 10 mg wyciągu znasion lnu, 400 mg wapnia, 5µg witaminy D3, 1,4 mg witaminy B6, 12 mg witaminy E, 0,2 mg kwasu foliowego. Estrogen therapy should be used with caution in women with hypoparathyroidism as estrogen-induced hypocalcemia may occur. Exacerbation Of Endometriosis

Depression, migraine, paresthesia, dizziness, anxiety, irritability, mood swings, nervousness, insomnia, headache Miscellaneous In a small number of case reports, substantial increases in blood pressure have been attributed to idiosyncratic reactions to estrogens. In a large, randomized, placebo-controlled clinical trial, a generalized effect of estrogens on blood pressure was not seen. Hypertriglyceridemia The effects are related to the content of soybean and hop cone extracts, which help alleviate menopausal symptoms, such as hot flashes, sweating, anxiety, and irritability. Curb JD, et al. Venous Thrombosis and Conjugated Equine Estrogen in Women Without a Uterus. Arch Int Med. 2006;166:772-780.In the WHI estrogen-alone substudy, the risk of VTE (DVT and PE) was increased for women receiving daily CE (0.625 mg)-alone compared to placebo (30 versus 22 per 10,000 women-years), although only the increased risk of DVT reached statistical significance (23 versus 15 per 10,000 women-years). The increase in VTE risk was demonstrated during the first 2 years 3. Should a VTE occur or be suspected, estrogen-alone therapy should be discontinued immediately. Zastosowanie: Climea Forte to produkt przeznaczony dla kobiet w okresie menopauzy. To źródło specjalnie dobranych składników, które pomagają utrzymać dobre samopoczucie w okresie menopauzy. First-pass metabolism in the gastrointestinal tract rapidly breaks down estradiol tablets before entering the systemic circulation. The bioavailability of oral estrogens is said to be 2-10% due to significant first-pass effects. The esterification of estradiol improves the administration (such as with estradiol valerate) or to sustain release from intramuscular depot injections (including estradiol cypionate) via higher lipophilicity. After absorption, the esters are cleaved, which leads to the release of endogenous estradiol, or 17β-estradiol. receiving reports on adverse effects (the legal basis for processing is a legal obligation to which Aflofarm is subject – Article 6(1)(c) of the GDPR);

Climea Forte - suplement diety zawierający izoflawony sojowe, wyciąg z szyszek chmielu, wapń i witaminy, wpływające korzystnie na organizm kobiet w okresie menopauzy. Preparat przeznaczony dla dorosłych kobiet.

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Studies of the addition of a progestin for 10 or more days of a cycle of estrogen administration, or daily with estrogen in a continuous regimen, have reported a lowered incidence of endometrial hyperplasia than would be induced by estrogen treatment alone. Endometrial hyperplasia may be a precursor to endometrial cancer. replying to a question/request concerning products, cooperation or business of Aflofarm – the legal basis for processing is your consent or a legitimate interest of the Controller – Article 6(1)(a) and (f) of the GDPR; In the WHI estrogen-alone substudy, no overall effect on coronary heart disease (CHD) events (defined as nonfatal MI, silent MI, or CHD death) was reported in women receiving estrogen-alone compared to placebo 2.

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